Evaluation of monoaminergic levels after acute administration of standardized extract of Justicia pectoralis in mice

Autores/as

  • Edith Teles Venâncioa Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara. Adress: Coronel Nunes de Melo, 1127, CEP 60.431-270, Fortaleza - Ceará
  • Alana Gomes de Souza Universidade Federal do Ceará
  • Klistenes Alves de Limaa
  • Michele Albuquerque Jales de Carvalhoa master; contributed to preparation of the manuscrit
  • Denia Alves Albuquerque de Souzaa
  • João Victor Souza Oliveiraa
  • Luzia Kalyne Almeida Moreira Leala
  • Marta Maria de França Fontelesa

Palabras clave:

Plants, Medicinal, Justicia, Biogenic Monoamines, Neuropharmacology, Mice

Resumen

Introduction: Justicia pectoralis is used as antiinflamatory, antimicrobial, bronchodilator, and sedative, and some studies have shown that it also acts in the Central Nervous System.
Objective: To evaluate effects of aqueous standardized extract of Justicia pectoralis (SEJP) in the monoamine levels of animals to elucidate the underlying neurochemical mechanisms associated.
Methods: Extract was administered intragastrically to male mice at single dose of 200 mg/kg at a volume of (10 mL/kg). One hour after the drug administration, the animals were sacrificed by decapitation, and the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST) were dissected. The High-Performance Liquid Chromatography (HPLC) method was used for determining levels of noradrenaline (NA), dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA).
Results: The work showed that SEJP decreased DA, DOPAC, NE (p< 0.01) and 5-HT (p< 0,05) levels in the prefrontal cortex. The basal level of NE in the hippocampus was significantly reduced (p< 0.05) when compared to control group. The treatment also decreased DA (p< 0.001), DOPAC (p< 0.01) and HVA (p< 0,001) levels in the striatum.
Conclusion: The findings showed that SEJP decreased the monoamines levels in the brain areas observed and suggest that Justicia pectoralis has potential clinical applications in the management of psychiatric disorders.

Biografía del autor/a

Alana Gomes de Souza, Universidade Federal do Ceará

Departamento de Fisiologia e Neurofarmacologia

Klistenes Alves de Limaa

Master; contributed to experimental research

Denia Alves Albuquerque de Souzaa

graduation student (scholarship in scientific initiation

João Victor Souza Oliveiraa

graduation student (scholarship in scientific initiation)

Luzia Kalyne Almeida Moreira Leala

professor doctor; research´s co-advisor

Marta Maria de França Fontelesa

professor doctor; research´s advisor

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Publicado

2019-03-11

Cómo citar

1.
Teles Venâncioa E, de Souza AG, Alves de Limaa K, Albuquerque Jales de Carvalhoa M, Alves Albuquerque de Souzaa D, Souza Oliveiraa JV, et al. Evaluation of monoaminergic levels after acute administration of standardized extract of Justicia pectoralis in mice. Rev Cubana Farm [Internet]. 11 de marzo de 2019 [citado 13 de marzo de 2025];51(4). Disponible en: https://revfarmacia.sld.cu/index.php/far/article/view/128

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ARTÍCULOS ORIGINALES