Design of a Facial Serum with Beehive Products and Aloe Vera

Abstract

Introduction: Skin aging is a natural and inevitable process that can delay and minimize its effects by avoiding certain factors that accelerate it or with the use of cosmetics and techniques designed for that purpose. The natural products of the beehive and Aloe vera are recognized for their beneficial contribution to skin care.

Objective: To design a facial serum with the use of biological active ingredients such as beehive products and Aloe vera aqueous extract.

Methods: To study the influence of the type of colloid and polyol on the characteristics of the preparation, an experimental statistical design of quadratic D-optimal mixture was developed, in which independent variables were glycerin, xanthan gum and sorbitol (70%) and dependent variables were pH and density of the formulation.  By means of numerical optimization, an optimum formulation was established and characterized according to appearance, pH and density. The influence of temperature on the stability of the elaborated serum was analyzed.

Results: The type of colloid and polyol had a significant influence on the characteristics of the formulation. The experimental mixing design applied showed that the independent variables studied influence the density and pH difference (t = 0 and t = 5 days), adjusting both variables to a quadratic model. The optimum formulation had a behavior similar to that predicted by the design and showed no physical modifications to temperature changes (38 ± 2 °C and 8 ± 2 °C) during seven days.

Conclusions: The experimental design and optimization allowed the establishment of an optimal formula that when evaluated provided satisfactory results.