Inhibition of intestinal transit in albino mice by ethanolic extract of <em>Senecio nutans</em> Schultz-Bip leaves

Abstract

Introduction: In Peru, as in other developing countries, gastrointestinal disorders such as diarrhea and abdominal cramps are very common. The population usually uses medicinal plants as a solution because of their easy access and availability, but many of them lack scientific evidence to support their beneficial effects on health.

Objective: Evaluate the inhibitory effect of intestinal transit of ethanolic extract of Senecio nutans Schultz-Bip leaves in albino mice.

Methods: Phytochemical screening was performed as a preliminary test. The inhibitory effect was based on the in vivo model of intestinal transit, with activated charcoal as a marker of intestinal motility, and as an inducer of diarrhea it was used castor oil. Four groups of five male mice (Mus musculus) BALB/c were randomly formed. The first group without any treatment (control); the second with the standard loperamide 1 mg/kg; the other groups, plant extract at 100 mg/kg and 200 mg/kg.

Results: The phytochemical analysis showed a greater presence of flavonoids. Ethanolic extract from S. nutans Schultz-Bip leaves slowed the intestinal transit of activated charcoal in a dose-dependent manner of 100 mg/kg (33.58%) and 200 mg/kg (24.34%); the second dose was similar to standard loperamide which was 15.22% (p< 0.05).

Conclusions: It was demonstrated that the ethanolic extract of S. nutansSchultz-Bip delayed the intestinal transit, with a dependent dose by inhibition of intestinal motility in mice.