The Situation of Antibiotic Resistance in Patients with Antibiogram in Intensive Care Units CUs

Abstract

Introduction: Antibiotic resistance is one of the most emerging global health problems today, and is particularly acute in hospital intensive care units in low- and middle-income countries.

Aim: To determine the antibiotic resistance rates of common bacteria in intensive care units of two hospitals in Vietnam.

Methods: A retrospective cross-sectional study was conducted. Data were extracted from electronic medical records of patients 18 years of age or older who had positive bacterial cultures from January 2020 to June 2022. Demographic information, medical history, and antibiotic susceptibility test results were collected from patients at two hospitals. Data were analyzed using Python 3.8.

Results: Acinetobacter spp. was most prevalent in Phu Tho hospital (27.5 %), while Klebsiella spp. was dominant in 175 Military hospital (28.0 %). Acinetobacter spp, Klebsiella spp. and Pseudomonas aeruginosa showed high levels of drug resistance to all antibiotic families, particularly to cephalosporins, carbapenems and fluoroquinolones (75 % to 100 %), their multiresistencia rates ranged from 83.8 % to 95.8 %. Conclusions: The prevalence of antimicrobial resistance among intensive care unit patients in two Vietnamese hospitals was exceptionally high, with alarming multidrug resistance rates of Acinetobacter, Klebsiella, and Pseudomonas aeruginosa.