Brain redox status in non-clinical model of social drinker

Abstract

Introduction: Oxidative stress is an entity with marked participation in the development of neuronal damage in the case of addictions, mainly in alcoholism. However, most reported clinical and non-clinical studies explore the stages of alcoholism and abstinence, so early-stage studies are insufficient.

Objective: Evaluate the brain redox status of Wistar rats in a social drinker model.

Methods: Redox markers of protection (superoxide dismutase, catalase, reduced glutathione) and damage (malondialdehyde) were determined in a social drinker model in Wistar rats.

Results: A redox imbalance was observed at the brain level, evidenced by the variation of antioxidant enzymes and malondialdehyde´s concentration levels in the ethanol consuming group.

Conclusions: The cerebral redox imbalance observed in Wistar rats, in a social drinker model, is representative of an incipient lipid peroxidation that shows that in the non-clinical model of social drinker there is neuronal damage.