Effect of cresophene on the contractile dynamics of arterial vascular smooth muscle

Abstract

Introduction: Cresophene is a commonly used antiseptic and antimicrobial used as an intra-conductive medication in endodontics. There are few scientific reports on its effects on arterial vascular smooth muscles and the regulation of local blood flow.

Objective: Determine the effect of cresophene on the contractile dynamics of arterial vascular smooth muscle according to its concentration and time of application.

Methods: A preclinical experimental research was conducted using 30 rings of external carotid arteries obtained from Wistar rats. The rings were placed in an organs bath and pre-activated with vasoactive substances, then the tension developed by the vascular smooth muscle after the addition of cresophene was recorded, in different concentrations and during different time intervals.

Results: Cresophene produced 49.1% vascular relaxation. The greatest decrease in tone occurred with the use of solutions at 10%. Wilcoxon tests of the ranges with signs showed significant differences between the initial base tension and that recorded ten minutes after the addition of the drug for solutions of 7% and 10%, respectively.

Conclusions: The cresophene induced in vitro relaxation of the arterial smooth vasculature through a drug-mechanical excitation-contraction coupling, which increased depending on the time and concentration of the drug.